Products supplied by ReSyn Biosciences (Pty) Ltd are for research purposes only. ReSyn products are not to be used for diagnostic, therapeutic or commercial purposes. Commercial means any use resulting in monetary gain, including, but not limited to, incorporation in a kit, repackaging and re-formulation. Please enquire about sub-licenses for commercial use.
Support: Proprietary polymer microspheres containing iron oxide (magnetite) Binding capacity: > 100 µg per mg support Bead size: 5-10 µm average Formulation: 20 suspension in 20% ethanol
Multi-mode HILIC microparticles for pre-Mass Spectrometry sample cleanup
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The range of possible sample contaminants, variability in starting material, & range of possible reagents for sample preparation has resulted in variability in data generated from mass spectrometry. Current methodologies and tools for sample clean-up prior to digestion and MS analysis require the use of in-line column chromatography, desalting columns/membranes, and or packed tips for partitioning. Although some of these techniques are broadly applicable, they are not routinely automatable, or don’t provide the option for parallel processing for high-throughput. In order to fully automate clean-up we have developed a versatile magnetic mixed-mode HILIC with broad applicability for the removal of common contaminants required in the solubilization and denaturation of proteins. The use of magnetic beads are gaining in popularity due to the ability to automate clean-up procedures, reducing sample handling, and providing massively parallel sample processing. MagReSyn® HILIC provides a highly reproducible and fully automatable solution for parallel protein sample clean-up prior to MS analysis. The product is compatible with a range of common contaminants which interfere in the generation of high quality data from MS analysis of samples.
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Testimonials: The HILIC method is fast, easy, and reliable. It is also far easier than FASP and less prone to contamination from PEG. I highly recommend it.” Prof Jason Held, Assistant Professor, Department of Medicine, Oncology Division, Washington University School of  Medicine in St Louis, USA We’ve been using MagReSyn HILIC beads as part of our peptide clean up step on dozens of projects over the last  year. This easy-to-use method has given us another great tool for dealing with complex samples, particularly those  that have been exposed to surfactants and detergents which would otherwise confound analyses. As with the other  products we use from ReSyn, we’ve come to rely on it as a robust, reliable method for the wide range of projects we  pursue as a core facility. Dr Ryan Leib, Director of Proteomics, Stanford, USA Using MagReSyn-HILIC greatly improved the purity of our samples. I highly recommend it. It resulted in both better  quality and reproducibility of our mass spec data.” Prof Blagoy Blagoev, Head of research, Department of Biochemistry and Molecular Biology, University of Southern  Denmark